EAU 2025 Guidelines: Renal Cell Carcinoma
Evidence-based recommendations on the diagnosis, staging, prognostic stratification, and management of RCC across localised, locally-advanced, and metastatic disease.
European Association of Urology — Official Recommendations
19 Guidelines|EAU 2025|For Educational Use Only
Evidence-based recommendations on the diagnosis, staging, prognostic stratification, and management of RCC across localised, locally-advanced, and metastatic disease.
Diagnosis, risk stratification, treatment, and surveillance of non-muscle-invasive bladder cancer (TaT1 and CIS) urothelial carcinoma.
Diagnosis, staging, and treatment of muscle-invasive (cT2–T4) and metastatic urothelial bladder cancer, covering neoadjuvant chemotherapy, radical cystectomy, bladder-sparing trimodality therapy, and systemic treatment of metastatic disease.
Diagnosis, risk stratification, kidney-sparing and radical surgical management, peri-operative systemic therapy, and follow-up of urothelial carcinoma of the renal pelvis and ureter.
Multi-society recommendations for screening, diagnosis, staging, treatment, and follow-up of prostate cancer — from early detection through localised, biochemically recurrent, hormone-sensitive metastatic, and castration-resistant disease.
Diagnosis, staging, and management of germ cell tumours (seminoma and non-seminoma) across all clinical stages, with risk-adapted treatment driven by IGCCCG prognostic groups and fertility preservation.
Diagnosis, staging, and stage- and sex-specific management of primary urethral carcinoma, a rare (<1% of GU malignancies) cancer covering urothelial, squamous and adenocarcinoma histologies.
EAU-ASCO joint recommendations on pathology, diagnosis, staging, and multidisciplinary management of penile squamous cell carcinoma, including organ-sparing surgery, sentinel node biopsy, and multimodal therapy.
Full-spectrum management of urinary stone disease — diagnostic imaging, metabolic evaluation, acute renal colic, interventional treatment (SWL, URS, PCNL), special populations, and recurrence prevention.
Diagnosis and management of urethral strictures in male, female, and transgender patients, covering endoluminal treatment (DVIU, dilatation), urethroplasty, posterior urethral injury, and follow-up.
Diagnosis, treatment, and prevention of bacterial UTIs across the spectrum — cystitis, pyelonephritis, urosepsis, catheter-associated UTI, prostatitis, epididymitis, Fournier's gangrene, GU TB, and peri-procedural prophylaxis.
Evaluation and management of injuries to the kidney, ureter, bladder, urethra, and external genitalia — blunt, penetrating, and iatrogenic — with haemodynamic stability as the primary management criterion.
Assessment, conservative management, drug therapy (alpha-blockers, 5-ARIs, antimuscarinics, beta-3 agonists, PDE5-i), and the full range of surgical options for benign prostatic obstruction stratified by prostate volume.
Assessment and management of LUTS in women — stress, urge, and mixed incontinence, overactive bladder, female BOO, nocturia, prolapse-associated LUTS, urinary fistulae, and urethral diverticula.
Diagnosis and bio-psychosocial management of Chronic Primary Pelvic Pain Syndromes — primary prostate, bladder, scrotal, urethral, and anorectal pain syndromes, plus pudendal neuralgia and pelvic floor dysfunction.
Management of neurogenic lower urinary tract dysfunction (NLUTD) in adults with SCI, MS, Parkinson's, stroke, and spina bifida — prioritising upper tract protection, continence, and quality of life.
Diagnosis and management of male sexual dysfunction (ED, ejaculatory disorders, low desire), penile conditions (Peyronie's, curvature, priapism), male hypogonadism, and male infertility.
Full breadth of paediatric urological conditions — phimosis, undescended testes, hypospadias, varicocele, VUR, hydronephrosis, stones, posterior urethral valves, DSD, paediatric tumours, and emergencies.
Full kidney transplantation pathway — donor selection (living and deceased), retrieval and preservation, recipient assessment, surgery, immunosuppression, and management of surgical and immunological complications.
Educational use only. These guidelines are reproduced for study purposes. Always refer to the official EAU website at eau.org for the latest clinical recommendations.